Common Routes of Administration
◆ Rat, mouse [gavage, intraperitoneal injection, intravenous injection (bolus, infusion), subcutaneous/intradermal injection, intramuscular injection]
◆ Beagle dog [gavage, capsule/tablet (oral), intravenous injection (bolus, infusion), subcutaneous/intradermal injection, intramuscular injection]
◆ Rhesus/cynomolgus monkey [gavage, capsule/tablet (oral), intravenous injection (bolus, infusion), subcutaneous/intradermal injection, intramuscular injection]
◆ Minipig [gavage, capsule/tablet (oral), intravenous injection (bolus, infusion), subcutaneous/intradermal injection, intramuscular injection, transdermal administration]
◆ Rabbit [gavage, intravenous injection (bolus, infusion), subcutaneous/intradermal injection, intramuscular injection, transdermal administration]
Special Routes of Administration
◆ Intraocular administration (drops, intraconjunctival, retrobulbar, anterior chamber, subretinal, suprachoroidal)
◆ Intranasal administration (drops, spray)
◆ Skin and mucosa
◆ Vaginal and rectal administration
◆ Intravesical administration
◆ Intrathecal administratio
◆ Intracavitary administration (intracranial, intra-articular, intratumoural)
◆ Surgery for implants
◆ Inhalation administration (oral and nasal exposure systems)
Sampling Techniques
◆ Blood sampling: Rat and mouse: fundus/sinus vein, tail vein, jugular vein, heart, abdominal aorta/ vein. Rabbit: marginal ear vein, heart, inguinal artery/vein. Beagle dog and monkey: veins of limbs, inguinal artery/vein. Minipig: precaval vein
◆ Urine and fecal sampling via metabolic cage
◆ Tissue sampling (paraffin, frozen, special handling etc.)
◆ In vivo collection techniques: Aqueous humor collection (rat, rabbit, dog, monkey); cerebrospinal fluid collection (rat, dog, monkey); liver biopsy (rat, dog, monkey); bone marrow aspiration (dog, monkey, pig)